SECTION 1 What Is Lupus?
1 History of Lupus
2 Definition and Classification of Lupus and Lupus-Related Disorders
3 The Epidemiology of Lupus
SECTION 2 Pathogenesis
4 Overview of Lupus Pathogenesis
5 Genetics of SLE
6 Single Gene Defects and Autoinflammation: Relation to Lupus
7 Epigenetics of Lupus
8 The Role of the Environment and Microbiome in Lupus
9 The Innate Immune System in SLE
10 B Cells and Generation of Antibodies
11 T cells
12 Immunoregulatory Cells and Networks in Lupus
13 Cytokines in Lupus
14 Metabolic Control of Immunopathogenesis in Systemic Lupus Erythematosus
15 Animal Models of Systemic Lupus Erythematosus (SLE)
SECTION 3 Mechanisms of Tissue Injury
16 Abnormalities in Clearance of Immune Complexes and Dying Cells in Lupus
17 Complement and Systemic Lupus Erythematosus
18 Apoptosis and Inflammatory Forms of Cell Death
19 Tissue Damage in Lupus: Free Radicals and Fibrosis
20 Lupus Nephritis
21 Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus
22 Pathogenesis of Cutaneous Lupus
23 Pathogenesis of Neuropsychiatric Lupus
24 Pathogenesis of Sjögren Syndrome
SECTION 4 Autoantibodies
25 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes
26 Antibodies Against Extractable Nuclear Antigens(RNP, Sm, SS-A/Ro, and SS-B/La)
27 Other Autoantibodies: Antibodies to C1q, Lipoprotein, and Endothelial Cells
28 Pathogenesis of Antiphospholipid Antibody Syndrome
29 Drug-Induced Lupus
SECTION 5 Clinical Aspects of Lupus Erythematosus
30 Overview and Clinical Presentation
31 Skin Disease in Cutaneous Lupus Erythematosus
32 The Musculoskeletal System and Bone Metabolism
33 Lupus and the Cardiovascular System
34 Pulmonary Manifestations of Systemic Lupus Erythematosus
35 Lupus and the Nervous System: Clinical Presentation, Diagnosis, and Treatment
36 Gastrointestinal and Hepatic Manifestations
37 The Gut Microbiome and Lupus Pathogenesis
38 Hematologic and Lymphoid Abnormalities in SLE
39 Neonatal Lupus: Pathogenesis and Clinical Approaches
40 Pregnancy and Reproductive Health Issues in Systemic Lupus Erythematosus
41 Systemic Lupus Erythematosus in Childhood and Adolescence
42 Clinical Aspects of Antiphospholipid Syndrome
43 Lupus and Infections
44 Ocular, Aural, and Oral Manifestations of Lupus
45 Clinical Aspects of Sjögren’s Disease
46 Clinical Presentations of Lupus in the Kidney and Urogenital System
47 The Endocrine System and Hormones in Lupus
SECTION 6 Assessment of Lupus
48 Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Laboratory Tests in Systemic Lupus Erythematosus
49 Differential Diagnosis and Disease Associations
50 Incomplete Lupus, Undifferentiated Connective Tissue Disease, and Mixed Connective Tissue Disease
51 Clinical Markers, Metrics, Indices, and Clinical Trials
SECTION 7 Management of Lupus
52 Principles of Therapy, Local Measures, and NSAIDs
53 Antimalarial Medications
54 Systemic Glucocorticoid Therapy for SLE
55 Immunosuppressive Drug Therapy
56 Complementary and Integrative Health Approaches
57 Specialized and Niche Therapies
58 Adjunctive and Preventive Measures
59 Management of Cutaneous Lupus Erythematosus
60 Targeted Therapies in SLE
61 Management of Lupus Nephritis
62 Management of Sjögren Disease Syndrome
SECTION 8 Outcomes
63 Socioeconomics, Disparities, and Disability
64 Prognosis and Mortality of Systemic Lupus Erythematosus
65 Future Directions: Therapeutics
66 Expanding the Opportunities to Effectively Treat Patients: Clinical Considerations